Session 8: Hip Arthroplasty
16. November
09:30 - 11:00
Lokale: 202-205
Chair: Peter Horstman and Søren Overgaard
64. Femoral head size does not influence metal ion levels after metal-on-polyethylene total hip arthroplasty: a 5-year report from a randomized controlled trial
Kristine Ifigenia Bunyoz1, Georgios Tsikandylakis2, 3, Kristian Mortensen1, Kirill Gromov1, Maziar Mohaddes2, 3, Henrik Malchau3, 4, Anders Troelsen1
1. Department of Orthopaedic Surgery, Copenhagen University Hospital,
Hvidovre, Denmark
2. Department of Orthopaedics, Sahlgrenska University Hospital,
Gothenburg, Sweden
3. Department of Orthopaedics, Institute of Clinical Sciences,
Sahlgrenska Academy, University of Gothenburg, Sweden
4. Harris Orthopaedic Laboratory, Department of Orthopaedics,
Massachusetts General Hospital, Boston, USA
Background: In metal-on-polyethylene (MoP) THA large femoral
metal heads are designed to increase stability and
reduce dislocation risk. Theoretically, the increased
head size could lead to increased taper corrosion
with the release of metal ions and adverse reactions.
Aim: Using blood ion measurements, we aim to
investigate the potential association between
femoral head size and metal-ion release after MoP
THA.
Materials and Methods: 96 patients were enrolled at two different centers
and randomized to receive either a 32-mm metal
head or a 36-44 mm metal head (the largest
possible fitting the thinnest available polyethylene
insert). Blood metal ions and PROMs (OHS, UCLA)
were measured at two- and five-year follow-ups.
Results: Both 2- and 5-year median chrome, cobalt, and
titanium levels were below taper corrosion indicative
ion levels. At 5 years, median chrome, cobalt, and
titanium levels were 0.5 µg/L (0.50-0.62), 0.24 µg/L
(0.18-0.30), and 1.16 µg/L (1.0-1.68) for the 32-mm
group, and 0.5 µg/L (0.5-0.54), 0.23 µg/L (0.17-
0.39), and 1.30 µg/L (1-2.05) for the 36-44 mm
group, with no difference between groups (p=0.825,
p=1.000, p=0.558). At 2 years, 7 versus 4 patients
had elevated ions in the 32-mm versus 36-44 mm
group. At 5 years, 6 versus 7 patients had elevated
ions in the 32-mm versus 36-44 mm group. At 5
years, median UCLA score was lower in the 36-44
mm group (p=0.020). The remaining PROMs
showed no differences between groups.
Interpretation / Conclusion: 5 years after the insertion of MoP THAs, we found
no differences in the blood metal ion levels between
32 mm heads and 36-44 mm heads and no
corrosion-related revisions. As taper corrosion can
debut after 5 years, there is still a need for long-term
follow-up studies on the association between head
size and corrosion in MoP THA.
65. No association between season of the year and risk of prosthetic joint infection after primary total hip arthroplasty: A cohort study on 58,449 patients with osteoarthritis from the Danish Hip Arthroplasty Register
Rajzan Joanroy1,2, Jens K Møller2,3, Sophie Gubbels4, Søren Overgaard5, Claus Varnum1,2
1.Department of Orthopaedic Surgery, Lillebaelt Hospital - Vejle, Denmark
2.Department of Regional Health Research, University of Southern Denmark,
Denmark
3.Department of Clinical Microbiology, Lillebaelt Hospital - Vejle, Denmark
4.Division of Infectious Disease Preparedness, Statens Serum Institut, Denmark
5.Department of Orthopedic Surgery and Traumatology, Copenhagen University
Hospital, Bispebjerg, Denmark
6.Department of Clinical Medicine, Faculty of Health and Medical Sciences,
University of Copenhagen
Background: The most devastating complication after total hip
arthroplasty (THA) is prosthetic joint infection
(PJI). Published danish surveillance data from
the Healthcare-Associated Infections Database
have indicated seasonal variation in primary THA
and risk of PJI revision with a higher incidence
during summer season.
Aim: We investigated the association between season
and risk of PJI revision and any revision following
primary THA.
Materials and Methods: This nation-wide register-based cohort study
identified 58,449 patients from the Danish Hip
Arthroplasty Register (DHR) with unilateral
primary THA performed due to osteoarthritis
from 2010-2018. From Danish health
registries, we retrieved information on
Charlson Comorbidity Index (CCI),
immigration, death, microbiological data on
intraoperative biopsies, cohabitation status
and meteorological data from The Danish
Meteorological Institute. Summer was defined
as June-September, and THAs performed
during winter (October-May) were used as
controls. The follow-up for all patients was 1
year. Primary outcome was revision due to
PJI confirmed or likely: the composite of
revision with any culture-positive biopsy or
reported PJI to DHR. The secondary outcome
was any revision. The cumulative incidences
and the adjusted relative risk (RR) with 95%
confidence intervals (CI) were calculated by
season of the primary THA. We adjusted for
age, sex, CCI, cohabitation status, fixation
type and duration of antibiotic treatment in
relation to primary THA.
Results: At 1-year follow-up, 1,507 patients were revised,
of which 632 were due to PJI. The cumulative
incidence of PJI for THAs performed during
summer and winter was 1.1% (CI 1.0-1.3) and
1.1% (CI 1.0-1.2) and for any revision 2.7% (CI
2.5-3.0) and 2.5% (CI 2.4-2.7), respectively. The
adjusted RR for PJI revision was 1.1 (CI 0.9 –
1.3) and for any revision 1.1 (CI 1.0-1.2) for
THAs performed during summer vs. winter.
Interpretation / Conclusion: We found no association between summer and
the risk of PJI revision or any revision for patients
with primary THA. Hence, the published
surveillance data could not be verified in the
present study. It seems safe to perform primary
THA during the summer season.
66. The effect of perioperative analgesia on persistent pain after total hip and knee arthroplasty - a systematic review and meta-analysis
Jens Laigaard1,2,3, Anders Peder Højer Karlsen2,4, Mathias Maagaard2,3, Troels Haxholdt Lunn3,4, Ole Mathiesen2,3, Søren Overgaard1,3
1) Dept. of Orthopaedic Surgery and Traumatology, Copenhagen University
Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark; 2) Centre for
Anaesthesiological Research, Dept. of Anesthesiology, Zealand University Hospital,
Køge, Denmark; 3) Dept. of Clinical Medicine, University of Copenhagen,
Copenhagen, Denmark; 4) Dept. of Anesthesia and Intensive care, Copenhagen
University Hospital Bispebjerg and Frederiksberg, Denmark.
Background: Pain during rehabilitation from surgery is
associated with persistent pain. This occurs in
around 9 to 20% of patients after total hip or knee
arthroplasty (THA/KA). The main reason for this,
is believed to be central sensitisation, where the
pain centres become hypersensitive after
experiencing intense pain.
Aim: To investigate the effect of perioperative
analgesic interventions in reducing persistent
pain after THA and KA.
Materials and Methods: This was a systematic review and meta-analysis
of randomised trials on perioperative analgesic
interventions for osteoarthritis patients
undergoing elective THA/KA. The protocol was
registered (CRD42021284175) and published
(PMID 35325472). Two authors independently
screened records, extracted data, and assessed
risk of bias. The primary outcome was pain
scores 3-24 months postsurgically, reported as
absolute mean differences (95% confidence
interval) on the 0-100 visual analogue scale.
Results: We searched CENTRAL, MEDLINE, and
Embase up to October 19, 2021, and
identified 38,202 unique records. We
screened 892 articles and found 725 eligible
trials, but pain outcomes 3-24 months
postsurgically was only available from 37
trials, despite contact to authors of all eligible
trials. All 37 trials were at high risk of bias.
Most included trials investigated
glucocorticoids (10 trial arms, 5369 patients),
local infiltration analgesia (7 trial arms, 1932
patients), and gabapentinoids (6 trial arms,
1770 patients). We found no effect of
glucocorticoids (-0.3 mm [95% CI -0.8 to
0.3]), local infiltration analgesia (0.0 mm
[-0.4 to 0.4)) or gabapentinoids (-3.0 mm
[-27.9 to 21.9]) on pain assessed at rest after
3-24 months. Similarly, we found no effect of
glucocorticoids (0.2 mm [-0.4 to 0.7]), local
infiltration analgesia (-1.4 mm [-4.0 to 1.1]) or
gabapentinoids (2.8 mm [-1.3 to 6.8]) on pain
assessed during movement. Other outcomes
of interest, including serious adverse events,
were rarely reported.
Interpretation / Conclusion: Few trials on analgesic interventions for THA/KA
reported long-term pain outcomes. All trials were
at high risk of bias, and we did not find any
evidence for or against perioperative analgesic
interventions for reduction of persistent
postsurgical pain.
67. Association between metabolic syndrome and patient-reported outcome after hip and knee arthroplasty - Results from 2,901 procedures performed in a high-volume centre
Rasmus Reinholdt Sørensen1, Signe Timm1, Lasse Enkebølle Rasmussen1, Claus Lohman Brasen2, Claus Varnum1
1. Department of Orthopaedic Surgery, Lillebaelt Hospital - Vejle;
2. Department of Biochemistry and Immunology, Lillebaelt Hospital - Vejle
Background: Metabolic syndrome (MetS) is a common term
used for metabolic deficiencies that can lead to
cardiovascular disease, diabetes and other
lifestyle-related conditions. Estimations are that
30% of the middle-aged population in Denmark
suffers from MetS. It is unknown how MetS
influences the outcome after hip and knee
arthroplasty.
Aim: Primary aim was to investigate the change in
patient-reported outcome (PRO) from baseline to
12 months after hip and knee arthroplasty in
patients with MetS compared to patients without
MetS. Secondly, PRO was compared at baseline,
3 and 24 months after surgery.
Materials and Methods: During May 1st, 2017 to November 30th,
2019 a cohort of 2,760 patients undergoing
2,901 hip and knee arthroplasties was
established. Data from national registries and
a local database were used to determine the
presence of MetS and the patients´ scores on
Oxford Hip Score (OHS) or Oxford Knee
Score (OKS), UCLA Activity Score (UCLA),
Forgotten Joint Score (FJS) and EQ-5D-5L
score at baseline, 3, 12 and 24 months after
surgery.
Primary outcome was the change from
baseline to 12 months in OHS and OKS.
Secondary outcome was OHS and OKS at 3
and 24 months as well as UCLA, EQ5D-5L
and FJS at 3, 12 and 24 months after surgery.
Mixed effect linear regression, adjusted for
age, sex, comorbidity and smoking, was
applied to present marginal mean and
associated 95% confidence intervals.
Results: fifty-two percent of the cohort met the criteria for
MetS. Both groups showed an increase in OHS
(MetS group 23 (22-23), non-MetS group 21 (21-
23)) and OKS (MetS-group 18 (18-19), non-MetS
group 18 (18-19)) at 12 months follow-up. The
difference between groups did not reach
statistical significance (OHS p=0.39 and OKS
p=0.97).
Similar improvements were seen in UCLA, FJS
and EQ-5D-5L at every time point.
Interpretation / Conclusion: Patients with metabolic deficiencies meeting the
criteria for MetS reach the same improvement in
PRO as individuals without MetS up to 24
months after hip and knee arthroplasty.
69. Long term evaluation of an Ultra-Short femoral neck preserving and proximal loading hip implant – a 10-year follow-up study
Martin Peter Nielsen1, Janus D Christensen1, Thomas Jakobsen1, Poul Torben Nielsen
1. Department of Orthopaedics, Aalborg University Hosptial;
Background: Using radio stereometric analysis (RSA), we have
previously shown good fixation of the ultra-short
stem Primoris® at midterm follow-up (5 years). Bone
mineral density (BMD) evaluations have shown
promising results with preservation of proximal bone
stock. Few studies have evaluated long term follow
up on BMD, migration and patient satisfaction of an
ultra-short stem.
Aim: The aim of this study was to investigate bone
remodeling, implant migration analysis (RSA) and
patient related outcome measures (PROMs) in
patients treated with the Primoris ® stem with a 10-
year follow-up
Materials and Methods: 50 patients (5 females and 45 males), mean age of
52 with end-stage osteoarthritis were treated with
the Primoris® between 2011-13. Using DEXA scans
we analyzed bone mineral density (BMD) in four
different regions of interest (ROI). Implant migration
was assessed using RSA. PROMs were evaluated
with Harris Hip score, Oxford Hip score, WOMAC,
EQ-5D score and UCLA activity score at the same
follow up intervals. Follow up examinations were
performed at day 1, 6 weeks, 6 months, 12 months,
2 years, 5 years and 10 years postoperatively.
Results: BMD showed a decrease in ROI1 (10.7%), ROI2
(12.7%), ROI3 (12.5%), ROI4 (4,.%) from day 0 to
10 years.
Patient satisfaction at 10-year follow-up remained
high with median values of Harris Hip score 98,
Oxford Hip score 47, WOMAC 97 , EQ-5D score 1,
UCLA activity score 7.
RSA analysis showed minimal migration of the
prosthesis in translation(X,Y,Z) and rotation(X,Y,Z)
with a mean maximum total point motion at 10 years
only of 0,79 mm.
Interpretation / Conclusion: This 10-year follow up study of the Primoris® stem
revealed minimal migration, which is in accordance
with migration patterns of traditional uncemented
stems. In regards to preserving proximal bone stock
for eventual later revision and the risk of fracture,
results are encouraging with only minimal stress-
shielding and PROMs comparable to patients
treated with a standard uncemented stem.
70. Accelerations Recorded by Low-Frequency Wearable Sensors as Effective Discriminators of Knee and Hip Osteoarthritis
Arash Ghaffari1, Pernille Damborg Clasen1, Rikke Vindberg Boel1, Andreas Kappel1, Thomas Jakobsen1, Søren Kold1, Ole Rahbek1
1. Interdisciplinary Orthopaedics, Aalborg University Hospital.
Background: Wearable inertial sensors can detect abnormal
gait associated with knee or hip osteoarthritis
(OA). However, few studies have compared
sensor-derived gait parameters between patients
with hip and knee OA or evaluated the efficacy of
sensors suitable for remote monitoring in
distinguishing between the two.
Aim: Our study seeks to examine the differences in
accelerations captured by low-frequency
wearable sensors in patients with knee and hip
OA and classify their gait patterns.
Materials and Methods: We included patients with unilateral hip and knee
OA. Gait analysis was conducted using an
accelerometer ipsilateral with the affected joint on
the lateral distal thighs. Statistical parametric
mapping (SPM) was used to compare
acceleration signals. The k-Nearest Neighbor (k-
NN) algorithm was trained on 80% of the signals’
Fourier coefficients and validated on the
remaining 20% using 10-fold cross-validation to
classify the gait patterns into hip and knee OA.
Results: We included 42 hip OA patients (19 females,
age 70 [63-78], BMI of 28.3 [24.8-30.9]) and
59 knee OA patients (31 females, age 68 [62-
74], BMI of 29.7 [26.3-32.6]). The SPM
results indicated that one cluster (12-20%)
along the vertical axis had accelerations
exceeding the critical threshold of 2.956
(p=0.024). For the anteroposterior axis, three
clusters were observed exceeding the
threshold of 3.031 at 5-19% (p = 0.0001), 39-
54% (p=0.00005), and 88-96% (p = 0.01).
Regarding the mediolateral axis, four clusters
were identified exceeding the threshold of
2.875 at 0-9% (p = 0.02), 14-20% (p=0.04),
28-68% (p < 0.00001), and 84-100% (p =
0.004). The k-NN model achieved an AUC of
0.79, an accuracy of 80%, and a precision of
85%.
Interpretation / Conclusion: In conclusion, the Fourier coefficients of the
signals recorded by wearable sensors can
effectively discriminate the gait patterns of knee
and hip OA. In addition, the most remarkable
differences in the time domain were observed
along the mediolateral axis.
71. Impact of self-perceived stress on the risk of opioid use after Total Hip Arthroplasty in osteoarthritis patients
Edwards Nina M.1, Klenø André S.2, Pedersen Alma B.2
1. Department of Orthopaedic Surgery, Regionshospitalet Horsens, Denmark;
2. Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
Background: Opioids are commonly used to treat pain after total hip arthroplasty (THA) surgery, however continued opioid use is seen in 16 % of patients 12 months after THA surgery. Increasing evidence show that psychological factors can affect pain and opioid use after surgery. However, little is known regarding the impact of a history of stress on opioid use after THA.
Aim: To examine the association between perceived stress and the risk of continued opioid use after THA in patients with osteoarthritis.
Materials and Methods: The 2013 and 2017 nationwide population-based health survey was used to identify 1,729 patients who completed a self-reported Perceived Stress Scale and who later on received a primary THA, identified through the Danish Hip Arthroplasty Registry. Patients were categorized into two groups: high level of stress and low level of stress (including no stress). The outcome was continued opioid use defined as = 2 opioid dispensing 1-12 months after THA identified in the Danish National Health Service Prescription Database. We calculated prevalences of continued opioid use. We calculated the adjusted prevalence ratios (aPR) with 95% confidence intervals using log-binomial regression and adjusting for sex, age, comorbidities, and education. We calculated median morphine milligram equivalents (MME) for the entire year as the opioid dose multiplied by an MME conversion factor.
Results: Overall, 258 (15%) patients reported high level of perceived stress, and 26% of these had continued opioid use. 1,471 (85%) patients reported low level or no stress, and 15% of these had continued opioid use. The aPR for continued opioid use was 1.42 (1.11-1.80). The MME dose was 1000 for patients, who reported high level of perceived stress and 645 for patients, who reported low level or no stress.
Interpretation / Conclusion: Patients, who report high level of perceived stress before THA have a higher risk of continued opioid use and consume higher MME dose in the first post-operative year after THA than patients, who report low level or no stress. We examined important pre-existing patient characteristics and found important differences contributing to continued opioid use after THA.
72. Status on the true dislocation risk one year after primary total hip arthroplasty (THA) based on data from the Danish Hip Arthroplasty Register and the Danish National Patient Register (LPR3-version)
Lars L. Hermansen1,2, Thomas F. Iversen2, Pernille Iversen3, Søren Overgaard4,5
1. Department. of Orthopedics, University Hospital of Southern Denmark,
Esbjerg;
2. Department of Regional Health Research, University of Southern
Denmark, Odense;
3. The Danish Clinical Quality Program and Clinical Registries;
4. Department of Orthopedic Surgery and Traumatology, Copenhagen
University Hospital, Bispebjerg;
5. Department of Clinical Medicine, Faculty of Health and Medical
Sciences, University of Copenhagen;
Background: Dislocation is one of the leading indications
for hip revision, but most patients are still
treated by closed reduction only. The true
burden of this complication has historically
been difficult to measure truthfully. In 2019,
we presented the true dislocation risk from
2010-2014 after conducting a nationwide
review of patient files, and we initiated the
work of implementing a new quality indicator
in the Danish Hip Arthroplasty Register
(DHR) based on the new Danish National
Patient Register (DNPR - LPR3 version).
Aim: Prior to planned onset of the dislocation
indicator in the 2022-annual DHR report,
our aim with this study was to present the
current national status of the true one-year
dislocation risk after primary THA.
Materials and Methods: We included 5.415 primary THAs inserted
from 1/7 2019 to 31/12 2019 and identified
every hospital contact with the Danish
healthcare system within the first
postoperative year based on data from the
DNPR. To identify every dislocation, we
manually reviewed patient files containing
more than 1.750 hospital contacts. All public
hospitals and private clinics were included.
Results are presented as proportions with
95% confidence intervals.
Results: We identified 243 dislocations in 152 THAs
corresponding to a true one-year dislocation
risk of 2.8% (2.4-3.3). During the follow-up,
37% of the patients suffered additional
events of dislocation. THA due to
osteoarthritis resulted in 2.5% (2.1-3.0)
dislocations, while the risk was 4.5% (2.3-
7.7) and 5.3% (2.8-9.1) in patients with
acute femoral neck fracture and sequalae
after earlier hip fracture surgery,
respectively. The results varied within the
five regions of Denmark from 1.4% (0.9-2.3)
to 5.4% (3.6-7.6), and between hospitals
from 0% to 9.6% (3.2-21.0).
Interpretation / Conclusion: The true one-year dislocation risk after
primary THA was 2.8%. This level
corresponds well with our findings in the
2010-2014 cohort. The next step will be to
validate our algorithm based on LPR3-data.
The quality indicator in the upcoming DHR
annual reports will contribute to identify both
hospitals and implant-related factors
associated with high dislocation rates and
improvement potential.
73. 49 cases of revision knee- and hip arthroplasty with Sonication for diagnosis of possible bacterial infection
morten boye petersen1, mikkel Rathsach andersen1
1. Department of Orthopaedics, Gentofte, Gentofte-Herlev University Hospital
Background: Diagnostics of possible infection in revision hip or
knee arthroplasty, has so far essentially been by
taking five tissue biopsies, as described by
Kamme 1981. However, it is often experienced
that tissue samples are without significant
bacterial diagnostics, even though the surgeon's
experience is that the field is infected. Based on
knowledge of biomembrane formation, sonication
has been developed as a method for diagnosing
periprosthetic infection (PJI).
Aim: To evaluate results with the first 49 cases using
sonication, the sonication result was compared
with the results of culture of tissue biopsies.
Materials and Methods: 49 implants removed during hip or knee
revision of all courses from 2017 to 2023
were sent for sonication. According to EBJIS
classification, preoperative 24 cases were
with unlikely infection, 21 with infection likely
and 4 with confirmed infection. If significant
bacterial growth was found when culturing the
sonication liquid, this was taken as diagnostic
of bacterial infection. For all cases, five
biopsies were taken a.m. Kamme. If two or
more tissue biopsies showed growth of the
same bacteria, this was taken as diagnostic
for bacterial infection. Results after the two
analysis methods were compared.
Results: In 28 operations, neither tissue biopsies nor
sonication found diagnostic signs of bacteria. In
14 cases, sonication found bacteria, typically low
virulence bacteria, with no growth in tissue
samples. In 6 cases, both sonication and tissue
samples found bacteria, and in all 6 cases, the
same bacterial strain. In 1 operation, sonication
found no growth, while tissue biopsies (3/5)
found growth of Staphylococcus aureus
Interpretation / Conclusion: Sonication seems to have a role in bacterial
diagnostic in revision surgery for PJI.
Typically, low-virulence biomembrane forming
bacteria such as e.g. Staph. Epidermidis is
detected.
In 14 cases (28%), bacteria could be
detected by sonication, where tissue biopsies
found no bacteria. In the cases where there
was both growth by sonication and 2 of 5
possitve tissue cultures , there was good
agreement in the bacterial diagnosis.
However, in its current structure, the method
is expensive and resource-demanding, which
gives limitations to its use.