Session 3: Pediatrics
15. November
09:00 - 10:30
Lokale: 202-205
Chair: Bjarne M Madsen and Louise Klingenberg
21. Age-related trends in unintentional injuries among children and adolescents in an urban Danish population 1980-2021. A study of 292,737 cases.
Frederik Haller1,2, Jens Martin Lauritsen1,2, Christian Færgemann1,2
1. Department of Orthopaedic Surgery and Traumatology, Odense University
Hospital.
2. Orthopaedic Research Unit, University of Southern Denmark.
Background: Pediatric unintentional injuries remain a
common cause of morbidity. However, no larger
study has described the age and gender
stratified epidemiology of unintentional injuries
among children and adolescents.
Aim: The study aimed to describe the age and gender
stratified epidemiology of unintentional injuries in
children and adolescents in an urban Danish
population from 1980-2021.
Materials and Methods: A retrospective study of all children and
adolescents aged 0-17 years treated for
lesions due to unintentional injuries at
Odense University Hospital 1980-2021. We
extracted information about age, gender,
place of injury, time of injury, and diagnoses
from the emergency department register. We
estimated gender specific annual incidence
rates (IRs) in different age groups (0-4, 5-9,
10-14, and 15-17 years) per 1000
population/years. The severity was
measured using a diagnose-based tool,
which transformed diagnoses into mild or
severe injuries.
Results: Overall, 292,737 unintentionally injured
children and adolescents were included. The
median age was 10 years for both gender
and 57.4% were boys. The overall IR was
241.2 (CI: 240.2-242.2) for boys and 187.5.
(CI: 186.5-188.4) for girls. The highest IR
was in the age group 15-17 years for boys
and 10-14 years for girls, respectively 275.6
(CI: 273.1-278.1) and 231.6 (CI: 229.6-
233.5). The overall IR for severe injuries was
26.9 (CI: 26.6-27.3) for boys and 20.4 (CI:
20.0-20.8). The highest IR for severe injuries
was in the age group 10-14 years in both
gender. The IRs for severe injuries
decreased significantly in the 10-14 and 15-
17 years age groups for both genders and
the 5-9 years age group for boys. The upper
limbs were the most frequently injured. Bone
fractures accounted for 14.5% of all lesions.
Injury time, injury place, and diagnoses
varied significantly between age groups.
Interpretation / Conclusion: The IRs varied significantly between the
different age groups throughout the study. The
study provides information about the injury
frequency, mechanism, location, and type of
injury, which are useful when coordinating the
resources at emergency departments and
planning preventive campaigns targeting
different age groups.
22. Birthweight correlates to pubo-femoral distances and alpha angles in hip ultrasound of newborns at six weeks of age.
Maria Tirta1, Michel Bach Hellfritzsch2,3, Rikke Damkjær Maimburg2,5,6,7, Mads Henriksenb2,3, Natallia Lapitskaya2,3, Søren Kold1,2, Bjarne Møller Madsen2,4, Ole Rahbek1,2, Hans-Christen Husum1,2
1. Interdisciplinary Orthopaedics, Aalborg University Hospital, Denmark
2. Danish Paedatric Orthopaedic Research, Denmark
3. Department of Radiology, Aarhus University Hospital, Denmark
4. Department of Children’s Orthopaedics, Aarhus University Hospital,
Denmark
5. Department of Midwifery, University College of Northern Denmark,
Aalborg
6. Department of Clinical Medicine, Aarhus University, Denmark
7. Department of Occupational Medicine, Danish Ramazzini Centre,
Aarhus University Hospital, Denmark
Background: There is inconsistency in the literature as to
the relationship between increased
birthweight and risk of developmental
dysplasia of the hip (DDH).
Aim: The aim of this study was to investigate the
correlation of birthweight to pubo-femoral
distances (PFD) values in DDH ultrasound,
as well as if increased birthweight is
negatively correlated to Graf a angles in
newborns undergoing hip ultrasound at five-
six weeks of age as well as correlation with
gender.
Materials and Methods: Newborns’ data and ultrasound
measurements were collected during a one-
year study period from October 2021 to
October 2022. Information recorded
included birthweight, gestational week,
gender, age at examination, and at
ultrasound measurements. We excluded
multiple births since newborns from multiple
births are usually lighter, as well as born
more premature, newborns born at 37
gestational week or less, and newborns with
incomplete information. Simple and multiple
linear regression analysis were performed
to evaluate the association of birthweight
and PFD, and secondly that of birthweight
and a angle.
Results: 670 newborns (1340 hips) were included in
this study with equal distribution of males
and females. Birthweight was statistically
significant higher for male newborns 3712 ±
450 grams vs 3555 ± 428 grams (p<0.001).
Increased birthweight was positively
correlated to PFD values (crude coefficient
= 0.245 (95% CI: 0.127; 0.363)) the
correlation was still present after adjusting
for gender, family history, and breech
presentation (adjusted coefficient 0.253
(95% CI: 0.132; 0.373). The stratified model
for males was statistically insignificant for
both the crude coefficient (p=0.163) and the
adjusted (p=0.06). The effect of birthweight
on a measurement for the females was
statistically significant (crude coefficient
-0.939 (95% CI: -1.828; -0.050); adjusted
coefficient -0.926 (95% CI: -1.029; -0.035)).
Interpretation / Conclusion: This study indicated that increases in
birthweight is positively correlated to PFD
measurements for both females and male
newborns, and negatively correlated to a
angle measurements in female newborns
screened for DDH at six weeks of age.
23. Point-of-care ultrasound in hip dysplasia screening increases detection rates by 60%.
Hans-Christen Husum1,2, Michel Bach Hellfritzsch2,3, Rikke Damkjær Maimburg2,5, Bjarne Møller-Madsen2,4, Mads Henriksen2,3, Natallia Lapitskaya2,3, Søren Kold1,2, Ole Rahbek1,2
1 Interdisciplinary Orthopaedics, Aalborg University Hospital, Denmark;
2. Danish Paedatric Orthopaedic Research, Aarhus University Hospital, Denmark www.dpor.dk;
3. Department of Radiology, Aarhus University Hospital, Denmark;
4. Department of Children’s Orthopaedics, Aarhus University Hospital, Denmark;
5. Department of Midwifery, University College of Northern Denmark, Aalborg
Background: Screening programmes for hip dysplasia (DDH) can be divided into selective referral of at-risk newborns for hip ultrasound (US) or universal referral of all newborns regardless of risk of DDH.
While selective screening is the predominant approach worldwide, it fails to reduce the rate of late diagnoses of DDH. Conversely, universal screening increases detection rates, but the need for examiners trained in the complex gold standard US examination method, makes it challenging to implement.
Aim: The present study investigates the effectiveness of a selective screening program using a point-of-care (POC) US examination method as a referral criterion for follow-up (FU) hip US and compares it to the traditional selective screening criteria of clinical examination and risk factor identification.
Materials and Methods: We prospectively included all newborns consented to receive a POC pubo-femoral distance (PFD) US screening in addition to the traditional screening for DDH at our institution. The PFD criterion was compared to traditional referral criteria in terms of sensitivity and specificity in detecting US abnormal hips as well as detection- and referral rates.
Results: We included 2,735 newborns of which 616 received a FU hip US. After exclusion 561 newborns were included for analysis. 317 newborns (11.6%) were referred by traditional screening criteria and 303 newborns (10.8%) were referred by the PFD criterion.
Sensitivities/specificities for detecting =Graf type IIa hips were: 17.4%/94.2% for clinical examination, 27.9%/47.5% for risk factors, 40.7%/51% for clinical examination and risk factors combined and 65.1%/72% for PFD examination using a cut-off of 5.8 mm. Differences in sensitivities and specificities between traditional referral criteria and the PFD criterion were statistically significant (p<0.01). PFD US increased the detection rate of immature hips (Graf IIa) by 72% and dysplastic hips (= Graf IIc) by 60% with similar referral rates
Interpretation / Conclusion: Early POC PFD US screening was significantly more effective in detecting abnormal hips than traditional selective screening. As PFD US is an accessible examination method, PFD screening may be a viable alternative to current selective screening for DDH.
24. National rates of pediatric fractures over a 20–year timespan in Denmark. A population-based cohort study
Anja Rønnov Lund1, Christian Færgemann1, Per Gundtoft2,3, Bjarke Viberg1,2
1. Department of Orthopaedic Surgery and Traumatology, Odense University
Hospital
2. Department of Orthopaedic Surgery and Traumatology, Hospital Lillebaelt
Kolding
3. Department of Orthopaedic, Aarhus University Hospital
Background: Previous reports on incidences of Scandinavian
pediatric extremity fractures have varied, as they
are often anatomically specific and based on
institution specific findings. In order to gain
knowledge of current and future burden on the
health care system, a national cohort
assessment is necessary.
Aim: To assess incidence, proportion and distribution
of pediatric extremity fractures in Denmark in
relation to age, sex, and anatomical areas.
Materials and Methods: A population-based cohort study with data
retrieved from the Danish National Patient
Registry between 1999-2018. All fractures were
registered following the 10th revision of the
International Classification of Diseases. Age was
categorized into four groups while anatomical
region was categorized into six groups. Incidence
rate was calculated based on national population
counts.
Results: We found a total of 668,595 pediatric
extremity fractures. The overall incidences
rates of extremity fractures were 3,164 (CI
3,156-3,171) per 100,000 person years for all
children.
The incidence rate increased from 3,078 (CI
3,044–3,111) in 1999 to 3,402 (CI 3,367–
3,437) in 2018. The distribution between sex
(57% boys) and age groups (11% 0-3 years,
21% 4-7 years, 33% 8-11 years, 36% 12-15
years) did not change during the study period.
The distribution was different from girls to
boys in the age groups, for girls 29% was in
the 8-11 years old and 41% in 12-15 years
old in comparison to 38% and 29% for the
boys.
The distribution between the anatomical
areas did not change markedly and there
were 111,212 upper arm fractures (15%),
293,786 (39%) lower arm, 181,599 (24%)
hand, 10,070 (1%) upper leg, 83,916 (11%)
lower leg and 80,914 (11%) foot fractures.
There were different distribution rates
between the age groups. The first and second
most frequent fracture areas were lower arm
(32% and 46%) and upper arm (27% and
23%) for 0-3 and 4-7 year old, lower arm
(44%) and hand (24%) for 8-11 year old, and
hand (34%) and lower arm (32%) for 12-15
year old.
Interpretation / Conclusion: The IR increased during the study period thereby
yielding a greater burden to the health care
system. There were different distribution rates of
fracture in relation to sex, age and anatomical
area.
25. Five-day accelerated Ponseti protocol is efficient and safe in the treatment of clubfoot
Vilhelm Engell1,2, Søren Ege Qwist1,2
1. Department of Orthopaedics, Aarhus University Hospital
2. Danish Pediatric Orthopaedic Research (DPOR)
Background: The management of clubfoot is non-operative with
repeated manipulation and casting as described by
Ponseti. Later accelerated versions of the Ponseti
method have been published. Studies suggest the
deforming forces are resolved within hours of the
manipulations. Recently, a method with daily
manipulation and casting have been described.
Aim: We have used a five-day accelerated Ponseti
method with daily manipulations and castings, in
order to accommodate parental needs for faster and
more convenient treatment since 2020.
Materials and Methods: In our accelerated one-week protocol we added an
ultrasound evaluation of the clubfeet at three months
to asses any deformation or damage to the
cartilage/bones and/or swelling of the soft tissues.
Otherwise, management was according to the
Ponseti method.
Results: This prospective consecutive series included all
clubfeet, where the parents chose the five-day
accelerated Ponseti protocol. All patients completed
the treatment with full clinical correction. 21 clubfeet
in 14 patients were included. Pirani score at
inclusion was median 6 (4-6) and at control at 3
months median 0 (0-0,5). Median 5 (4-5) casts to
obtain correction before Achilles tenotomy, which
was performed in all cases. Ultrasound evaluation at
three months; no signs of deformation or damage to
the cartilage/bones or soft tissue swelling was
observed. There were no early recurrences at 1year
follow-up. Pirani score at follow-up was median 0 (0-
½).
Interpretation / Conclusion: Morcuende et al. reported results of an
accelerated Ponseti protocol for clubfoot. Edema
of the feet was a concern. Hence, they
recommended 5-day casting interval. However,
others have found accelerated Ponseti
techniques to be effective and safe. The fact that
no feet had signs of deformation or damage to
the cartilage/bones or soft tissue swelling at
ultrasound evaluation at three months, indicates
that the five – day accelerated Ponseti protocol is
safe. A longer follow-up time may tell relapse
frequency. Overall acceleration of the Ponseti
method seems efficient and safe.
26. Knee-related Quality of Life, Symptoms, Pain, and Function in Sport and Recreational activities in adults with a history of adolescent Sinding-Larsen Johansson disease: A registry-based cohort study
Kasper Krommes1, Kristian Thorborg1,2, Jørgensen Amalie Bjerre1,3, Mathias Fabricius Nielsen1, Lasse Christensen4, Per Hölmich1,2
1. Sports Orthopedic Research Center – Copenhagen (SORC-C), Department of
Orthopedic Surgery, Copenhagen University Hospital, Amager-Hvidovre,
Denmark;
2. Department of Clinical Medicine, University of Copenhagen, Denmark;
3. Faculty of Physiotherapy, Center of Nutrition and Rehabilitation, University
College Absalon, Roskilde, Denmark;
4. Department of Sports Science and Clinical Biomechanics, University of
Southern Denmark, Odense, Denmark
Background: Sinding-Larsen Johansson Disease (SLJD) is a
common growth-related condition in
adolescence that causes knee pain and
decreased sports-participation. However, little is
known about its long-term consequences into
adulthood.
Aim: To investigate the long-term consequences of
SLJD based on self-reported knee health of
adults diagnosed with SLJD during adolescence
compared to normative data.
Materials and Methods: All adults aged 18-55 years, diagnosed in
Danish secondary care with SLJD during
1977-2020, were invited to complete a
survey on SLJD-history and current knee-
related health. Knee-related health was
assessed with the Knee Injury and
Osteoarthritis Outcome Score (KOOS) on
subscales Quality of Life (QoL), Symptoms,
Pain, and Sport/Rec. A priori we planned to
subgroup participants according to sex and
age (female/male; 18-25, 26-35, 36-45, 46-
55 years), and compare these to matched
subgroups from a healthy cohort (Williamson
et al. 2015, n=1000).
Results: 76 adults completed the survey (age
36.9±13 years, 45% male). Due to few
observations in the SLJD-subgroups, all
participants were compared to weighted
means from the entire healthy cohort across
KOOS subscales, showing clinically relevant
differences (QoL: -28 points, p<0.0001;
Symptoms: -14 points, p<0.0001; Pain: -15
points, p<0.0001; Sport/Rec subscale -32
points, p<0.0001). Adults reporting “a lot of
pain” vs. “little pain” during SLJD in
adolescence had decreased KOOS-
Symptom score (77 vs. 92 points, p<0.05).
Adults reporting being “some”/“very” limited
in their sports-participation during SLJD in
adolescence, had increased risk of having
“some”/“severe” symptoms from their SLJD
as adults (OR >1.30, p<0.05).
Interpretation / Conclusion: Adults diagnosed with SLJD in adolescence
seems to have decreased self-reported knee
health as adults when compared to healthy
populations. The degree of pain, and
limitations in sport and physical activity
during SLJD in adolescence is associated to
knee-related symptoms as adults. As it
seems SLJD can lead to reduced knee-
health in adulthood, and certain severity-
characteristics can result in a worse
prognosis, the information given during
clinical consultations with adolescents with
SLJD should reflect this.
27. Outcome of Pavlik Harness treatment for unstable hip dysplasia in infants
Mathias Hauge Bünger1, Line Holm Jensen1, Martin Gottliebsen1
1. Department of paediatric orthopaedics, Aarhus University Hospital
Background: There is general consensus that unstable
hips in infants require treatment if
spontaneous improvement doesn’t occur in
patients with hip dysplasia (DDH). Many
different braces and splints exist. In
Denmark, abduction bracing using the
Dennis-Brown rigid splint has traditionally
been used. However, globally the Pavlik
Harness (PHT) which is allowing hip motion
in abduction is most commonly used. We
report data of our experience with PHT of
infants with DDH.
Aim: The aim of the study was to describe efficiency
of PHT in our cohort of infant babies of unstable
DDH.
Materials and Methods: The cohort includes 61 infants (5 boys/56
girls) PH treated for 23/24h in the hip clinic at
AUH from 2020 to 2023. Decision of
treatment was based on a combination of
dynamic ultrasound (US) using a modified
Graf method showing hip instability and
clinical examination. In case of treatment,
patients were seen at a one week follow-up
to adjust the PH and do US to document the
femoralhead centered in the acetabulum. At
the one week mark parents were asked
about problems using the PH. After this, hips
were reviewed clinically and with dynamic
US every 4th week until normalization (a-
angle >60°, Cov>50% and stable) when PH
treatment was stopped.
Results: The mean age of the infants at PHT
beginning was 7.3 weeks (range 1-19), while
mean treatment duration was 8.1 week
(range 4-14). Of the 61 infants initiating PHT,
hip normalized in 51 pt (84%). PHT was
abandoned for a rigid DB splint in 6 patients
(10%) and for closed reduction and hips
spica casting in 3 patients (5%). 6 of 51
patients (12%) successfully PHT had an
acetabular index >30° at the radiographs age
6 months. In 52% (32/61) of the infants,
parents reported that their child appeared
unaffected. 4 of 61 (7%) reported problems
with breastfeeding, 23/61 (38%) had
sleeping problems and irritability the first
days. No parents terminated treatment by
the self.
Interpretation / Conclusion: The data show that a most unstable hips can be
successfully treated with the Pavlik Harness. In
a few patients the PH failed, typically in very
unstable hips in which the PH didn’t provide
enough abduction to keep the hips reduced or in
irreducible hips. The PH was well tolerated by
infants and parents.
28. Is Simple Talectomy a Beneficial Procedure for Severe Foot Deformity?
Marianne Frydendal Nielsen1,2, Jan Rölfing1,2, Line Kjeldgaard Pedersen1,2, Michael Davidsen1,2, Bjarne Møller-Madsen1,2
1. Department of Children's Orthopaedics, Aarhus University Hospital
2. Danish Paediatric Orthopaedic Research, www.dpor.dk
Background: Talectomy is rarely performed. Non-invasive
techniques are the gold standard to redress Severe
Neuromuscular Foot Deformity (SNFD). Yet,
talectomy may be considered for rigid, painful, or
neglected SNFD to obtain a stable, plantigrade and
pain-free foot. We present a 10-year follow-up
accessing radiological correction, functional
outcomes, complications, and patient satisfaction.
Aim: The aim of the study was to investigate whether
simple talectomy is a beneficial procedure.
Materials and Methods: This single centre retrospective case series
evaluated talectomies in 2012-2022. Simple
talectomy was combined with Steinman pin
fixation of calcaneus to tibia for approximately six
weeks. Main diagnoses included arthrogryposis
multiplex congenita and cerebral palsy. The
primary outcome was radiological correction
rates. Tibiotalar angle (TiTa) and tibiocalcaneal
angle (TiCa) were measured on mediolateral
projections. Talectomy indications were pain,
wounds, pressure marks, problems wearing
shoes/orthoses and residual/recurrent deformity
after former interventions. Secondary outcomes
were functional outcomes graded as
good/fair/poor based on degree of deformity and
pain. Validated patient-reported outcome
measures, i.e., EQ-5D-5L and two items from the
Scoliosis Research Society-30 Questionnaire
assessed health-related quality of life and patient
satisfaction.
Results: 19 talectomies in 11 patients were analysed.
Mean follow-up was 62 months (range 9-112
months). Mean TiTa prior talectomy was
137±17°. TiCa improved significantly with a
mean difference of -24°(95%CI=[-44;-5])(p˜0.02).
All 19 feet became plantigrade and pain-free with
no skin sores. Functional outcomes were graded
as 9/19(47%) good, 10/19(53%) fair and
0/19(0%) poor. 9/11(82%) patients could stand
with support versus 6/11(55%) before talectomy.
Four patients walked supported by aids prior
surgery (all bilateral cases). In-house walking
distance improved in three cases.
Parents/primary caregivers ranked their
satisfaction level between neutral and very
satisfied. Perceived health was rated with a
mean visual analogue scale score of 54±27 out
of 100, emphasizing complex medical conditions.
Interpretation / Conclusion: Simple talectomy is a beneficial procedure for
SNFD.
29. Scoping review of rotational guided growth in the growing bone
Ahmed Halloum1, Søren Kold1, Jan D. Rölfing2, Ahmed A. Abood1,3, Ole Rahbek1
1. Interdisciplinary Orthopaedics, Aalborg University Hospital;
2. Children’s Orthopaedics and Reconstruction, Aarhus University Hospital;
3. Orthopaedic Oncology and Reconstruction, Aarhus University Hospital
Background: Guided growth is routinely used to correct
angular deformities in long bones in children. It
has also been proven to be a viable method to
correct rotational deformities, but the concept is
not yet fully examined.
Aim: The aim of this scoping review is to understand
the extent and type of evidence in relation to the
use of guided growth for correcting rotational
deformities of long bones
Materials and Methods: Databases searched include Medline, Embase,
Cochrane Library, Web of Science and Google
Scholar.
All published and unpublished studies were
included.
All identified citations were collated and uploaded
into Rayyan.ai and screened by at least two
reviewers. Data from included studies were
extracted using a predesigned extraction tool.
Results: The search resulted in 3569 hits.
14 studies were included: 1 review, 3 clinical
trials and 10 pre-clinical trials.
The review covers guided growth for treating
angular deformities of lower limbs but
includes a paragraph about rotational
deformities.
Clinical trials: a total of 21 children (32 femurs
and 5 tibiae) were included. Surgical methods
were 2 canulated screws connected by cable,
PediPlates obliquely oriented, and separated
Hinge Plates connected by FiberTape.
Rotation was achieved in all but 1 child.
Adverse effects reported include limb length
discrepancy (LLD), knee stiffness and
rebound of rotation after removal of tethers.
2 pre-clinical studies were ex-vivo studies, 1
using 8-plates on Sawbones and 1 using
novel z-shaped plates on human cadaver
femurs.
There were 5 lapine studies (2 using femoral
plates, 2 using tibial plates and 1 using an
external device on tibia), 1 ovine (external
device on tibia), 1 bovine (canulated screws
and cable on metacarp) and a case-report on
a dog that had an external device spanning
from femur to tibia.
Rotation was achieved in all studies.
Adverse effects reported include implant
extrusions, LLD, articular deformities
(including menisci), joint stiffness and
rebound of rotation.
Interpretation / Conclusion: All included studies conclude that guided growth
is a viable treatment for rotational deformities of
long bones, but there is great variation in models
and surgical methods used, and in reported
adverse effects.
30. Measurement of anterior knee laxity with the Rolimeter® changes with flexion angle but not when a shortened Rolimeter® for smaller children is used
Maria Østergaard Madsen1, Susan Warming2, Robert Bennike Herzog2, Michael Rindom Krogsgaard1
1. Section for Sports Traumatology M51, Copenhagen University Hospital Bispebjerg-
Frederiksberg, Copenhagen, Denmark
2. Department of Physical and Occupational Therapy Bispebjerg and Frederiksberg
Hospital, Copenhagen, Denmark
Background: The most widely used instrument to measure
anterior tibial translation in the evaluation of anterior
cruciate ligament (ACL) sufficiency is the
Rolimeter®. Little is known about how knee flexion
in the interval 10-40 degrees affects laxity
measures. For smaller children the standard
Rolimeter® is too long to fit onto tibia, so to be able
to measure these children we have modified the
Rolimeter®, reducing the length by 1/3 - but whether
this modification influences the measurement of
anterior tibial translation is unknown.
Aim: To investigate if anterior tibial translation measured
by the Rolimeter® varies with knee flexion in the
interval 10-40 degrees, and when a standard or a
shortened (“pediatric”) Rolimeter® is used.
Materials and Methods: Fourty-eight children and adults with an isolated
ACL-rupture were measured with a standard
Rolimeter® and the “pediatric” Rolimeter® with 1/3
reduced length. All patients were measured in 10°,
20°, 30° and 40° degrees of flexion by two
independent observers.
Results: The weighted kappa showed that measurements
made with the standard Rolimeter® and the
”pediatric” version had moderate agreement. T-test
demonstrated that anterior tibial laxity was
significantly affected by the degree of knee flexion
showing higher values with increasing flexion in the
range 10°-40°. However, laxity of the injured and the
non-injured knee changed to the same extent with
knee flexion.
Interpretation / Conclusion: It is important that repeated measurements of
anterior tibial translation are made with the same
degree of knee flexion. The variance in laxity
dependent on flexion can be compensated for by
comparison with the non-injured side. The
shortened, “pediatric” Rolimeter® can be used in the
daily clinic to supply valid instrumented
measurements of ACL stability in smaller children.